title: "Research Articles" url: /helix-docs/articles/

Research Articles

Long-form publications, validation studies, and research reports from the Helix team.

Latest Publications

Validating a Multi-Contract Genome Editing Feasibility Framework

March 2024 | Empirical validation study

We validate a deterministic feasibility framework that generalizes across Prime Editor, Base Editor, and Cas12a systems against 30 curated literature cases.

Key findings:

Spearman ρ = 0.811 between CS and published outcomes
F1 = 0.872 for binary tractability classification
Strong correlation across all three modalities

Coming Soon

Historical case studies from the discovery campaign
Protocol validation for specific disease targets
Benchmark comparisons with other feasibility tools

Note: These articles represent completed research with frozen protocols. For active development on the Constraint → Strategy Engine, see Research: Decision Support.